Clinical efficacy and safety of sildenafil citrate (Viagra) in a multi‐racial population in Singapore: A retrospective study of 1520 patients
Identifieur interne : 001459 ( Main/Exploration ); précédent : 001458; suivant : 001460Clinical efficacy and safety of sildenafil citrate (Viagra) in a multi‐racial population in Singapore: A retrospective study of 1520 patients
Auteurs : Peter Huat Chye Lim ; Man Kay Li ; Foo Cheong Ng ; Sing Joo Chia [Singapour] ; David Consigliere [Singapour] ; Louis Gooren [Pays-Bas] ; Kok Kit Ng ; Malathy Munisamy ; Moorthy PeriananSource :
- International Journal of Urology [ 0919-8172 ] ; 2002-06.
English descriptors
- Teeft :
- Benign prostatic hyperplasia, Cardiovascular, Cardiovascular disease, Citrate, Cohort, Comorbid, Diabetes mellitus, Diabetic, Diabetic patients, Dysfunction, Effective dose, Erectile, Erectile dysfunction, Hypertension, Intracavernosal, Intracavernosal injections, Ischemic, Ischemic heart disease, Malay, Many patients, Medical history, Mellitus, Myocardial infarction, Other forms, Present cohort, Present study, Previous treatments, Satisfactory outcome, Several studies, Sexual activity, Singapore, Singaporean, Success rate, Successful patients, Total cohort, Urology, Viagra.
Abstract
Background: Sildenafil citrate (Viagra), a selective inhibitor of cGMP‐specific phosphodiesterase type‐5, has been used as an oral therapeutic drug for erectile dysfunction. The present paper is a clinical study of the success rate and side‐effects of the use of sildenafil in a multi‐racial population in Singapore.
Methods: From April 1999 to May 2000, 1520 patients were given sildenafil citrate. Of these, 912 patients (mean age, 54.6 years; age range, 22–99 years) were followed up and evaluated for clinical efficacy and safety of the drug. The mean duration of erectile dysfunction (ED) and follow‐up periods were 31.5 and 3.0 months, respectively.
Results: Satisfactory erections assessed by single global efficacy question (GEQ) occurred in 83% of patients, major side‐effects in the form of flushing (3.48%), headache (1.97%), blurred vision (1.25%), giddiness (1.18%), warmth (1.11%) and others (4.92%) were recorded in 127 patients (13.9%). Racially, Chinese men with ED had higher efficacy (85.7%), compared to Indian men (74.2%) and Malay men (72.8%). With respect to comorbid profiles, an efficacy of 77.8% (n = 271), 83.9% (n = 292), 86.4% (n = 44) and 83.3% (n = 199) was recorded in diabetic, hypertensive, ischemic heart disease patients and in benign prostatic hyperplasia patients, respectively. Patients who smoked (n = 135) and drank alcohol (n = 118) showed an efficacy of 80%. Baseline hormonal profiles of luteinizing hormone, follicle stimulating hormone, testosterone and prolactin did not affect the success rates of sildenafil citrate. Many patients had earlier received other forms of treatment (medicated urethral suppository for erection (MUSE; 84.9%); vacuum devices (86.8%), traditional medicines (100%) and other oral medications (89.2%)), but this did not influence the success rate of sildenafil citrate. But patients previously treated with prostaglandin‐E intracavernosal injections were less successful on sildenafil citrate (77.3%). In the total cohort, 50 mg sildenafil citrate was an effective dose in 49% of patients and 46.5% patients needed 100 mg sildenafil citrate, while 4.1% of the total cohort needed only 25 mg sildenafil citrate.
Conclusion: Oral sildenafil citrate has been shown to be an effective, safe and well tolerated drug in Singaporean men with ED, as in men from other parts of the world.
Url:
DOI: 10.1046/j.1442-2042.2002.00425.x
Affiliations:
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sort="Gooren, Louis" uniqKey="Gooren L" first="Louis" last="Gooren">Louis Gooren</name></author><author><name sortKey="Ng, Kok Kit" sort="Ng, Kok Kit" uniqKey="Ng K" first="Kok Kit" last="Ng">Kok Kit Ng</name></author><author><name sortKey="Munisamy, Malathy" sort="Munisamy, Malathy" uniqKey="Munisamy M" first="Malathy" last="Munisamy">Malathy Munisamy</name></author><author><name sortKey="Perianan, Moorthy" sort="Perianan, Moorthy" uniqKey="Perianan M" first="Moorthy" last="Perianan">Moorthy Perianan</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DE8AD97ED318F042905AD36B7A31C9C7E8AF3938</idno><date when="2002" year="2002">2002</date><idno type="doi">10.1046/j.1442-2042.2002.00425.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-FDGV75BF-8/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">003969</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003969</idno><idno 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Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Gooren, Louis" sort="Gooren, Louis" uniqKey="Gooren L" first="Louis" last="Gooren">Louis Gooren</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Free University Medical Hospital, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ng, Kok Kit" sort="Ng, Kok Kit" uniqKey="Ng K" first="Kok Kit" last="Ng">Kok Kit Ng</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Munisamy, Malathy" sort="Munisamy, Malathy" uniqKey="Munisamy M" first="Malathy" last="Munisamy">Malathy Munisamy</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Perianan, Moorthy" sort="Perianan, Moorthy" uniqKey="Perianan M" first="Moorthy" last="Perianan">Moorthy Perianan</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">International Journal of Urology</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF UROLOGY</title><idno type="ISSN">0919-8172</idno><idno type="eISSN">1442-2042</idno><imprint><biblScope unit="vol">9</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="308">308</biblScope><biblScope unit="page" to="315">315</biblScope><publisher>Blackwell Science Pty</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2002-06">2002-06</date></imprint><idno type="ISSN">0919-8172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0919-8172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Benign prostatic hyperplasia</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Citrate</term><term>Cohort</term><term>Comorbid</term><term>Diabetes mellitus</term><term>Diabetic</term><term>Diabetic patients</term><term>Dysfunction</term><term>Effective dose</term><term>Erectile</term><term>Erectile dysfunction</term><term>Hypertension</term><term>Intracavernosal</term><term>Intracavernosal injections</term><term>Ischemic</term><term>Ischemic heart disease</term><term>Malay</term><term>Many patients</term><term>Medical history</term><term>Mellitus</term><term>Myocardial infarction</term><term>Other forms</term><term>Present cohort</term><term>Present study</term><term>Previous treatments</term><term>Satisfactory outcome</term><term>Several studies</term><term>Sexual activity</term><term>Singapore</term><term>Singaporean</term><term>Success rate</term><term>Successful patients</term><term>Total cohort</term><term>Urology</term><term>Viagra</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Background: Sildenafil citrate (Viagra), a selective inhibitor of cGMP‐specific phosphodiesterase type‐5, has been used as an oral therapeutic drug for erectile dysfunction. The present paper is a clinical study of the success rate and side‐effects of the use of sildenafil in a multi‐racial population in Singapore.</div><div type="abstract">Methods: From April 1999 to May 2000, 1520 patients were given sildenafil citrate. Of these, 912 patients (mean age, 54.6 years; age range, 22–99 years) were followed up and evaluated for clinical efficacy and safety of the drug. The mean duration of erectile dysfunction (ED) and follow‐up periods were 31.5 and 3.0 months, respectively.</div><div type="abstract">Results: Satisfactory erections assessed by single global efficacy question (GEQ) occurred in 83% of patients, major side‐effects in the form of flushing (3.48%), headache (1.97%), blurred vision (1.25%), giddiness (1.18%), warmth (1.11%) and others (4.92%) were recorded in 127 patients (13.9%). Racially, Chinese men with ED had higher efficacy (85.7%), compared to Indian men (74.2%) and Malay men (72.8%). With respect to comorbid profiles, an efficacy of 77.8% (n = 271), 83.9% (n = 292), 86.4% (n = 44) and 83.3% (n = 199) was recorded in diabetic, hypertensive, ischemic heart disease patients and in benign prostatic hyperplasia patients, respectively. Patients who smoked (n = 135) and drank alcohol (n = 118) showed an efficacy of 80%. Baseline hormonal profiles of luteinizing hormone, follicle stimulating hormone, testosterone and prolactin did not affect the success rates of sildenafil citrate. Many patients had earlier received other forms of treatment (medicated urethral suppository for erection (MUSE; 84.9%); vacuum devices (86.8%), traditional medicines (100%) and other oral medications (89.2%)), but this did not influence the success rate of sildenafil citrate. But patients previously treated with prostaglandin‐E intracavernosal injections were less successful on sildenafil citrate (77.3%). In the total cohort, 50 mg sildenafil citrate was an effective dose in 49% of patients and 46.5% patients needed 100 mg sildenafil citrate, while 4.1% of the total cohort needed only 25 mg sildenafil citrate.</div><div type="abstract">Conclusion: Oral sildenafil citrate has been shown to be an effective, safe and well tolerated drug in Singaporean men with ED, as in men from other parts of the world.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>Singapour</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement></list><tree><noCountry><name sortKey="Li, Man Kay" sort="Li, Man Kay" uniqKey="Li M" first="Man Kay" last="Li">Man Kay Li</name><name sortKey="Lim, Peter Huat Chye" sort="Lim, Peter Huat Chye" uniqKey="Lim P" first="Peter Huat Chye" last="Lim">Peter Huat Chye Lim</name><name sortKey="Munisamy, Malathy" sort="Munisamy, Malathy" uniqKey="Munisamy M" first="Malathy" last="Munisamy">Malathy Munisamy</name><name sortKey="Ng, Foo Cheong" sort="Ng, Foo Cheong" uniqKey="Ng F" first="Foo Cheong" last="Ng">Foo Cheong Ng</name><name sortKey="Ng, Kok Kit" sort="Ng, Kok Kit" uniqKey="Ng K" first="Kok Kit" last="Ng">Kok Kit Ng</name><name sortKey="Perianan, Moorthy" sort="Perianan, Moorthy" uniqKey="Perianan M" first="Moorthy" last="Perianan">Moorthy Perianan</name></noCountry><country name="Singapour"><noRegion><name sortKey="Chia, Sing Joo" sort="Chia, Sing Joo" uniqKey="Chia S" first="Sing Joo" last="Chia">Sing Joo Chia</name></noRegion><name sortKey="Consigliere, David" sort="Consigliere, David" uniqKey="Consigliere D" first="David" last="Consigliere">David Consigliere</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Gooren, Louis" sort="Gooren, Louis" uniqKey="Gooren L" first="Louis" last="Gooren">Louis Gooren</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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